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KMID : 1007520150240031105
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Food Science and Biotechnology
2015 Volume.24 No. 3 p.1105 ~ p.1113
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Fucosylated Chondroitin Sulfate from Sea Cucumber Inhibited Islets of Langerhans Apoptosis via Inactivation of the Mitochondrial Pathway in Insulin Resistant Mice
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Jiang Wei
Li Shijie
Hu Shiwei
Wang Jignfeng
Song Wendong
Ji Lili
Wang Yaning
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Abstract
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The effects of fucosylated chondroitin sulphate from sea cucumber (CHS) on inhibition of pancreatic islet apoptosis in high-fat high-sucrose diet (HFSD)-induced insulin resistant mice were studied for 19 weeks. CHS treatment significantly (p<0.05) decreased fasting blood glucose, insulin, and tumor necrosis factor (TNF)-α levels, and increased the serum adiponectin level, improved insulin resistance, and repaired HFSD-injured islets of langerhans, compared with controls. CHS supplementation significantly (p<0.05) inhibited pancreas cell apoptosis via reduction of cytochrome c, caspase 9, and caspase 3 mRNA expressions, cytochrome c release into the cytoplasm, and caspase 9 and cleaved-caspase 3 protein expressions, compared with controls. These effects were associated with upregulation of Bcl-2 and Bcl-xL mRNA and protein expressions, and downregulation of Bax and t-Bid mRNA and protein expressions. Combination treatments with CHS and rosiglitazone synergistically protected pancreatic islets. CHS improves insulin resistance and protects islets of langerhans from apoptosis via inactivation of the intrinsic mitochondrial pathway.
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KEYWORD
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fucosylated chondroitin sulfate, sea cucumber, insulin resistance, apoptosis, mitochondrial pathway
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